Results of the search of scientific studies, publications and communications

Pregnant Sprague-Dawley rats were administered deltamethrin, at doses of 0.1, 1, 5, or 10 mg/kg/day, or di-n-hexyl phthalate (DnHP) (250 mg/kg/day), by gavage, from gestation day (GD) 13 to 19. Maternal toxicity was observed at 10 mg/kg/day, as evidenced by transient…

In a first study, rats were given diisooctyl phthalate (DIOP, CAS 27554-26-3) at 0, 0.1, 0.5, and 1 g/kg/day, by gavage, on gestation days 6 through 20 (GD). There was a significant increase in resorptions at 1 g/kg/day and a reduction in fetal weights at 0.5 and 1 g/kg…

N-ethyl-2-pyrrolidone (NEP) is an industrial solvent used in association or in replacement of N-methyl-2-pyrrolidone. Both are teratogenic in rats and are categorized as reproductive toxicants 1B by the European Commission. Nevertheless…

In utero exposure to the phthalate ester plasticizer, di-n-hexyl phthalate (DnHP) is known to affect the development of the male reproductive system and induce alterations in androgen-dependent tissues of the male rat offspring. Male reproductive…

Testing and assessment of chemicals for their endocrine disruption properties are a major concern for chemical safety. Besides regulatory studies which use standard markers (e.g. anogenital distance), more targeted mode of action studies can…

The solvent N-ethyl-2-pyrrolidone was evaluated in a 4-week repeated dose study in rats. NEP diluted in distilled water was administered by gavage to male and female Sprague-Dawley rats at doses of 0 (vehicle control), 5, 50, and 250 mg/kg/day for 28…

This study evaluates the developmental toxicity of two high molecular weight dialkyl phthalate esters, diundecyl phthalate (DUDP) and ditridecyl phthalate (DTDP). Sprague-Dawley rats were administered 0, 0.25, 0.50, or 1 g/kg/day of DUDP or DTDP, by gavage…

Pyrethroids are among the most commonly used classes of insecticides worldwide. Human exposure to pyrethroids is widespread, as evidenced by the presence of their metabolites in urine of adults, children, and pregnant and lactating women among…

Synthetic pyrethroids are present in numerous commercial insecticide formulations and have extensive worldwide indoor and outdoor applications, including agricultural, public, residential, and veterinary usages for pest control. Their…

Synthetic pyrethroids are used worldwide as insecticides. Their metabolites have been constantly measured in the urine of adults and children from the general population. There is increasing concern that they may induce sex-hormone disrupting…