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PUBLICATION 07/2025EL2018-002/P2025-025Tricresyl phosphate gestational exposure induced endocrine and metabolic disruptionsOrganophosphate flame retardants (OPFRs), including tricresyl phosphate (TCP), are incorporated into a wide variety of polymers to give them fire resistance. They are therefore present in numerous industrial and consumer products such as electrical…
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PRESENTATION 04/2016NOETUDE/C2016-072Evaluation of N-ethyl-2-pyrrolidone-induced liver effects in ratsN-ethyl-2-pyrrolidone (NEP) is an industrial solvent used in association or in replacement of N-methyl-2-pyrrolidone. Both are teratogenic in rats and are categorized as reproductive toxicants 1B by the European Commission. Nevertheless…
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PRESENTATION 10/2016NOETUDE/C2016-146Additional steroidogenesis endpoints in the fetal ratTesting and assessment of chemicals for their endocrine disruption properties are a major concern for chemical safety. Besides regulatory studies which use standard markers (e.g. anogenital distance), more targeted mode of action studies can…
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PRESENTATION 03/2015NOETUDE/C2015-041Evaluation of the effects of deltamethrin on the fetal rat testisPyrethroids are among the most commonly used classes of insecticides worldwide. Human exposure to pyrethroids is widespread, as evidenced by the presence of their metabolites in urine of adults, children, and pregnant and lactating women among…
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PRESENTATION 01/2014NOETUDE/C2014-015Developmental toxicity of phtalates. Read accross approachPhthalates are diesters of the ortho phthalic acid. They are extensively used as plasticizers, primarily for polyvinyl chloride (PVC), and as solvents. They are present in a large variety of consumer products and widespread exposure to multiple…
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