Results of the search of scientific studies, publications and communications

DEHP is a phthalate plasticizer of PVC, classified as a Category 1B reproductive toxicant (EU). Soft PVC are very often plasticized with 40% (w/w) phthalates. As DEHP is weakly bound, the risk of contamination and cutaneous penetration should be considered…

Phthalates are economically important products with the most used for the tonnage implemented annually in the European Union can exceed 500,000 tons. They are used as plasticizers for plastics to make them more flexible, mainly in the polyvinyl…

Outline of reasons and objectives
With service-based employment becoming increasingly proeminent, and nearly 10 million employees working in offices in France, Indoor Air Quality (IAQ) has become an issue for occupational health. However, the…

Testing and assessment of chemicals for their endocrine disruption properties are a major concern for chemical safety. Besides regulatory studies which use standard markers (e.g. anogenital distance), more targeted mode of action studies can…

Hexavalent chromium, the most toxic form of chromium, is listed in the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) list of substances of very high concern. For several decades, INRS has been studying the biomonitoring…

Multi-exposures to chemicals are frequent in the workplace, and represent a serious current issue. According to the results of the Sumer 2003 study, 20 % of employees could be exposed to at least five chemical agents. Among the chemical compounds…

At INRS, in 2012, a study on the need for epidemiological research in the working environment on endocrine disruptors (reproductive effect) pointed to phthalates (DiNP, DEHP) as a priority class of substances to be examined. It is expected that DiNP…

As an essential component of polycarbonate plastics and epoxy resins, Bisphenol A (BPA) is found in numerous industrial and consumer products, including electronic goods, household equipment, metallic food and beverage cans, bottles and dental…

Mixed exposures to chemical products often happen during work time and they are topical issues for occupational health. According to the 2003 Sumer Survey, 20% of French workers are exposed to 5 chemicals at least. Among hazardous chemicals, many…