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PUBLICATION 07/2025EL2018-002/P2025-025Tricresyl phosphate gestational exposure induced endocrine and metabolic disruptionsOrganophosphate flame retardants (OPFRs), including tricresyl phosphate (TCP), are incorporated into a wide variety of polymers to give them fire resistance. They are therefore present in numerous industrial and consumer products such as electrical…
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PRESENTATION 04/2016NOETUDE/C2016-072Evaluation of N-ethyl-2-pyrrolidone-induced liver effects in ratsN-ethyl-2-pyrrolidone (NEP) is an industrial solvent used in association or in replacement of N-methyl-2-pyrrolidone. Both are teratogenic in rats and are categorized as reproductive toxicants 1B by the European Commission. Nevertheless…
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PUBLICATION 08/2024EL2018-007/P2023-102Antifungal Climbazole alters androgenic pathways in mammalian cellsAmong antifungal agents used in pharmaceuticals (e.g., antimycotic foot care) and personal care products, the synthetic azole climbazole (CBZ; 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one) acts on the fungus Malassezia. Despite…
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PRESENTATION 03/2015NOETUDE/C2015-041Evaluation of the effects of deltamethrin on the fetal rat testisPyrethroids are among the most commonly used classes of insecticides worldwide. Human exposure to pyrethroids is widespread, as evidenced by the presence of their metabolites in urine of adults, children, and pregnant and lactating women among…
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