Results of the search of scientific studies, publications and communications

N-ethyl-2-pyrrolidone (NEP) is an industrial solvent used in association or in replacement of N-methyl-2-pyrrolidone. Both are teratogenic in rats and are categorized as reproductive toxicants 1B by the European Commission. Nevertheless…

N-vinyl-2-pyrrolidone (NVP) is mainly used as monomer in the production of polyvinylpyrrolidone or copolymers. Percutaneous absorption is an important source of exposure in the work environment. However, literature on this route of absorption…

The solvent N-ethyl-2-pyrrolidone was evaluated in a 4-week repeated dose study in rats. NEP diluted in distilled water was administered by gavage to male and female Sprague-Dawley rats at doses of 0 (vehicle control), 5, 50, and 250 mg/kg/day for 28…

The percutaneous route represents the second occupational exposure route for numerous industrial toxic substances. The word “Skin notation” appears whenever the contribution from this route to the total absorption by the body represents…

For testing skin absorption of chemical substances, OECD Test Guideline 428 (OECD, 2004)1 provides some recommendations as to how substances should be prepared:
“The test substance preparation (e.g., neat, diluted or formulated material containing…