Results of the search of scientific studies, publications and communications

N-ethyl-2-pyrrolidone (NEP) is an industrial solvent used in association or in replacement of N-methyl-2-pyrrolidone. Both are teratogenic in rats and are categorized as reproductive toxicants 1B by the European Commission. Nevertheless…

Bisphenol AF (BPAF) and 4,4'-Sulfonylbis[2-(prop-2-en-1-yl)phenol] (TGSA) are analogues of Bisphenol A (BPA). BPAF is commonly used in polymer synthesis, whereas TGSA finds application in thermal papers. BPAF is classified as toxic to reproduction 1B…

Bisphenol S (BPS) was introduced in many industrial and commercial applications as a presumed safer alternative to bisphenol A. However, concerns have been raised
surrounding skin absorption and potential persistence of BPS, and its related…

Bisphenol S (BPS) is widely used as a substitute for bisphenol A (BPA) in industrial applications, raising concerns about its dermal absorption and potential systemic toxicity. This study investigated the toxicokinetics of BPS following dermal…

The percutaneous route represents the second occupational exposure route for numerous industrial toxic substances. The word “Skin notation” appears whenever the contribution from this route to the total absorption by the body represents…

For testing skin absorption of chemical substances, OECD Test Guideline 428 (OECD, 2004)1 provides some recommendations as to how substances should be prepared:
“The test substance preparation (e.g., neat, diluted or formulated material containing…