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Author(s) : LAMBERT XOLIN A.M.

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EL2016-016 | 2016
Evaluation of N-ethyl-2-pyrrolidone-induced liver effects in rats NOETUDE/C2016-072 | 2016

N-ethyl-2-pyrrolidone (NEP) is an industrial solvent used in association or in replacement of N-methyl-2-pyrrolidone. Both are teratogenic in rats and are categorized as reproductive toxicants 1B by the European Commission. Nevertheless…
Repeated dose oral toxicity of N-ethyl-2-pyrrolidone in Sprague Dawley rats NOETUDE/P2016-057 | 2016

The solvent N-ethyl-2-pyrrolidone was evaluated in a 4-week repeated dose study in rats. NEP diluted in distilled water was administered by gavage to male and female Sprague-Dawley rats at doses of 0 (vehicle control), 5, 50, and 250 mg/kg/day for 28…

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