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PUBLICATION 09/2023EL2018-004/P2023-203Quantification of carbon nanotubes in biological matrices for toxicology purposesDespite numerous possible applications, the potential impact of Carbon Engineered Nanomaterials (CEN) on human health, particularly after exposure by inhalation, is still questioned. However, accurate quantification of CEN in the respiratory…
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PRESENTATION 06/2016NOETUDE/C2016-103Pulmonary toxicity and genotoxicity of carbon nanotubes in rats, a subacute inhalation studyDue to their physical and chemical properties, carbon nanotubes (CNTs) are among the most promising nanomaterials in terms of industrial use. In order to assess their toxicological properties, inhalation experiments performed in laboratory…
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PRESENTATION 07/2014EL2013-010/C2014-066DEVELOPMENT AND VALIDATION OF AN INHALATION SYSTEM SUITABLE FOR RODENT EXPOSURE TO NANOAEROSOLSDue to the growing use of nanoparticles in industrial processes, the number of workers potentially exposed is increasing while the toxicological effects of these compounds have not been fully characterized yet. Because inhalation represents…
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PRESENTATION 02/2016NOETUDE/C2016-020Pulmonary toxicity and genotoxicity of carbon nanotubes in rats, a subacute inhalation study.Due to their physical and chemical properties, carbon nanotubes (CNTs) are among the most promising nanomaterials in terms of industrial use. In order to assess their toxicological properties, inhalation experiments performed in laboratory…
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PRESENTATION 10/2015NOETUDE/C2015-079Brain inflammation and Blood Brain Barrier disruption after sub-acute inhalation exposure to titanium dioxide nanoparticle aerosol in aging ratsNotwithstanding potential neurotoxicity of Titanium dioxide nanoparticles (TiO2 NPs), the toxicokinetics and consequences on blood brain barrier (BBB) functions remain poorly characterized. We previously described the biodistribution…
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PRESENTATION 02/2016EL2013-010/C2016-018Titaninium dioxide-induced gene expression profile in rat lung, a sub-acute inhalation study.Due to the growing use of nanoparticles in industrial processes, the number of workers potentially exposed is increasing while the toxicological properties of these compounds are not fully known. Inhalation represents the main route of occupational…
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PRESENTATION 02/2016NOETUDE/C2016-025Development and validation of an inhalation system suitable for rodent exposure to carbon nanotubesDue to their physical and chemical properties, carbon nanotubes (CNTs) are among the most promising nanomaterials in terms of industrial use. In order to assess their toxicological properties, inhalation experiments performed on laboratory…
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PRESENTATION 06/2016EL2013-010/C2016-102TiO2-induced gene expression and protein profiles in rat lung: a subacute inhalation studyDue to the growing use of nanoparticles in industrial processes, the number of workers potentially exposed is increasing while the toxicological properties of these compounds are not fully known. Inhalation represents the main route of occupational…
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PUBLICATION 05/2023EL2018-005/P2023-092Effect of multi-walled carbon nanotube exposure on wild type and p53+/- rat lungCarbon nanotubes (CNTs) are nanomaterials that can be inhaled by employees during production or handling. One CNT, the Mitsui-7 (MWNT-7), has been classified by the International Agency for Research on Cancer as possibly carcinogenic to humans…
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PUBLICATION 07/2023EL2018-005/P2023-078Needle-like, short and thin multi-walled carbon nanotubes: comparison of effects on wild type and p53+/- rat lungsLes nanotubes de carbone (NTC) sont des nanomat riaux qui pr sentent un risque professionnel d inhalation lors de leur production ou de leur manipulation. Le Centre International de Recherche sur le Cancer a class un NTC, le Mitsui-7 (MWNT-7), comme…
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