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STUDY 01/2010B.4/1.087Studies of the in vitro genotoxic effects of nanostructured silica particles produced by different manufacturing processesOutline of reasons and objectives
Nanoparticles of synthetic amorphous silica (SAS) are produced in large quantities worldwide (1 million metric tons/year) and they have numerous industrial uses. SASs can be broken down into two main types depending…Learn more
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STUDY 01/2017ET2017-002
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PRESENTATION 05/2016NOETUDE/C2016-085In vitro cell transformation induced by amorphous silica nanoparticlesWorldwide production of silica nanoparticles is estimated to be one million tons per year. Unlike crystalline silica, silica nanoparticles which have an amorphous structure are so far not considered as carcinogen to humans by IARC. However…
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PRESENTATION 05/2016NOETUDE/C2016-087Epigenetic mechanisms involvement in in vitro cell transformation induced by micro- and nano-silica particlesEpigenetic mechanisms that are essential in normal cell growth have been found disrupted in several human diseases such as cancer. Epigenetic mechanisms include histone post-translational modifications, DNA methylation and non-coding…
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PRESENTATION 05/2016NOETUDE/C2016-089Epigenetic mechanisms involvement in in vitro cell transformation induced by micro- and nano-silica particlesEpigenetic mechanisms that are essential in normal cell growth have been found disrupted in several human diseases such as cancer. Epigenetic mechanisms include histone post-translational modifications, DNA methylation and non-coding…
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STUDY 01/2013ET2013-005Impact of sources and of the environment on the confinement of nanoparticulate pollutants by collective protective devicesA prior study on the effectiveness of collective protective devices in protecting against a nanometric pollutant led to confinement testing methods and to the establishment of the predominant influence of air flow on confinement. In order…
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STUDY 01/2016ET2016-004
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PUBLICATION 10/2023EL2018-006/P2023-065Can a 12-gene expression signature predict the cell transforming potential of tumor promoting agents in Bhas 42 cells?In the present study, we assess whether this signature would be the same for four other soluble transforming agents, i.e. mezerein, methylarsonic acid, cholic acid and quercetin. The treatment of Bhas 42 cells for 48h with mezerein modified the expression…
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