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Results of the search of scientific studies, publications and communications
Author(s) : FONTANA J.M.
9 results
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Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 2: intratracheal instillation and intravenous injection. B.4/1.088/P2014-010 | 2015Nanosized synthetic amorphous silicas (SAS) have been extensively used in food and tire industries. During industrial processes, they might be aerosolized leading to occupational exposure of workers mainly through inhalation. However, a few…
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Studies of the in vitro genotoxic effects of nanostructured silica particles produced by different manufacturing processes B.4/1.087 | 2010Outline of reasons and objectives
Nanoparticles of synthetic amorphous silica (SAS) are produced in large quantities worldwide (1 million metric tons/year) and they have numerous industrial uses. SASs can be broken down into two main types depending… -
Cytotoxicity and genotoxicity of panel of single- and multi-walled carbon nanotubes: in vitro effects on normal Syrian Hamster Embryo (SHE) and immortalized V79 hamster lung cells B.4/2.152/P2014-054 | 2014Carbon nanotubes (CNTs) belong to a very specific class of nanomaterials with unique properties. Because of their anticipated use in a wide range of industrial applications, their toxicity is of increasing concern.
In order to determine whether… -
In vitro comet and micronucleus assays do not predict morphological transforming effects of silica samples in Syrian Hamster Embryo cells B.4/2.152/P2015-072 | 2016Crystalline silica and asbestos have both been classified as carcinogenic by the International Agency for Research on Cancer (IARC). However, because of the limited data available, amorphous silica was not classifiable.
On the other hand, in vitro… -
Cytotoxic and genotoxic evaluation of different synthetic amorphous silica nanomaterials in the V79 cell line B.4/1.087/P2012-191 | 2015Synthetic silica nanoparticles (SNPs) are the most produced nanomaterials and have many industrial applications, but their hazard is still discussed. Manufactured SNPs occur in amorphous form and can be distinguished in three different types…
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Worldwide production of silica nanoparticles is estimated to be one million tons per year. Unlike crystalline silica, silica nanoparticles which have an amorphous structure are so far not considered as carcinogen to humans by IARC. However…
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Epigenetic mechanisms involvement in in vitro cell transformation induced by micro- and nano-silica particles NOETUDE/C2016-087 | 2016Epigenetic mechanisms that are essential in normal cell growth have been found disrupted in several human diseases such as cancer. Epigenetic mechanisms include histone post-translational modifications, DNA methylation and non-coding…
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Epigenetic mechanisms involvement in in vitro cell transformation induced by micro- and nano-silica particles NOETUDE/C2016-089 | 2016Epigenetic mechanisms that are essential in normal cell growth have been found disrupted in several human diseases such as cancer. Epigenetic mechanisms include histone post-translational modifications, DNA methylation and non-coding…
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Constructing, translating and validating a questionnaire. The example of EUROQUEST B.5/2.040/3566/NS178 | 1999Questionnaires are information gathering tools that are often irreplaceable in research. Multidimensional scales are best adapted to investigating diseases or disorders involving several components (such as depression or deterioration…
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