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PUBLICATION 04/2024EL2018-004/P2023-162Analysis of Carbon nanotube levels in organic matter: an inter-laboratory comparison to determine best practiceCarbon nanotubes (CNTs) are increasingly being used in industrial applications, but their toxicological data in animals and humans are still rare. To understand the effects of CNTs, their quantification in tissues, especially lungs, is crucial…
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PUBLICATION 09/2023EL2018-004/P2023-203Quantification of carbon nanotubes in biological matrices for toxicology purposesDespite numerous possible applications, the potential impact of Carbon Engineered Nanomaterials (CEN) on human health, particularly after exposure by inhalation, is still questioned. However, accurate quantification of CEN in the respiratory…
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PRESENTATION 04/2015NOETUDE/C2015-051Optimization of mineralization methods of TiO2 nanoparticles: Determination of titanium levels in rat organ tissuesTitanium dioxide nanoparticles (TiO2 NPs) are among the highest produced nanoparticles in the world today and are increasingly being incorporated into a wide range of construction and domestic products. Production on such a massive scale raises…
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PRESENTATION 10/2015NOETUDE/C2015-079Brain inflammation and Blood Brain Barrier disruption after sub-acute inhalation exposure to titanium dioxide nanoparticle aerosol in aging ratsNotwithstanding potential neurotoxicity of Titanium dioxide nanoparticles (TiO2 NPs), the toxicokinetics and consequences on blood brain barrier (BBB) functions remain poorly characterized. We previously described the biodistribution…
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STUDY 01/2013EL2013-010Study of the effect of agglomeration on the respiratory toxicological properties and the toxicokinetics of inhaled nanoparticles of titanium dioxide in ratsDue to the growing use of nanoparticles in industrial processes, the number of workers potentially exposed is increasing while the toxicological properties of these compounds are not fully known. Since these particles can be aerosolised, the…
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STUDY 01/2014EL2014-010Determining the parameters making it possible to assay intra-erythrocytic chromium: I - In vitro studyHexavalent chromium is the most toxic form of chromium. Currently, no biological exposure marker exists that is specific to hexavalent chromium. A bibliographic study has shown that Cr(VI) is incorporated into erythrocytes while the other species…
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PRESENTATION 12/2014NOETUDE/C2014-120Biokinetic comparison after single I.V. administration or chronic aerosol inhalation of TiO2 nanoparticles : impact on blood-brain barrierNotwithstanding the translocation of reported TiO2 nanoparticles (NPs) through biological barriers, the bio-distribution of TiO2NPs to the CNS and impact on the functions of the BBB remain poorly characterized. We report such evidence.
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PRESENTATION 05/2014NOETUDE/C2014-048Beryllium determination in urine at nanogram level for biomonitoring purposeBeryllium exposure is known to seriously affect health, and even very low levels of exposure may be toxic. It is therefore essential that biological or air-monitoring strategies adopted in the workplace are reliable and accurate over a range…
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PRESENTATION 02/2014NOETUDE/C2014-023Relationships between air and urinary concentrations of béryllium in Cu-foundry, Al- foundry and Al-smelter workersBeryllium occurrence in occupational areas is a major concern as low-level exposure could lead to development of beryllium sensitization (BeS) and of a chronic beryllium disease (CBD), a long latency granulomatous disorder that primarily affects…
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PRESENTATION 10/2014NOETUDE/C2014-090Human urine sample treatment before Beryllium determination for biomonitoring purposeBeryllium exposure is known to seriously affect health, and even very low levels of exposure may be toxic. It is therefore essential that biological or air-monitoring strategies adopted in the workplace are reliable and accurate over the whole…
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