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PRESENTATION 02/2014NOETUDE/C2014-025Biological monitoring of occupational exposure to di(2-ethylhexyl) phthalate (DEHP) in two cases: the French flexible-PVC industry and the use of vinyl glovesDEHP is a phthalate plasticizer of PVC, classified as a Category 1B reproductive toxicant (EU). Soft PVC are very often plasticized with 40% (w/w) phthalates. As DEHP is weakly bound, the risk of contamination and cutaneous penetration should be considered…
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STUDY 01/2013EL2013-001Biological assessment of occupational exposure to di(isononyl) phthalate (DiNP)Outline of reasons and objectives
Di(isononyl) phthalate (DINP) is mainly used as a plasticizer in the flexible PVC industry, as a substitute for di(2-ethylhexyl) phthalate (DEHP). The industrial process is based on extrusion, and then gelling, in order…Learn more
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PRESENTATION 10/2016NOETUDE/C2016-146Additional steroidogenesis endpoints in the fetal ratTesting and assessment of chemicals for their endocrine disruption properties are a major concern for chemical safety. Besides regulatory studies which use standard markers (e.g. anogenital distance), more targeted mode of action studies can…
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PUBLICATION 08/2024EL2018-007/P2023-102Antifungal Climbazole alters androgenic pathways in mammalian cellsAmong antifungal agents used in pharmaceuticals (e.g., antimycotic foot care) and personal care products, the synthetic azole climbazole (CBZ; 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one) acts on the fungus Malassezia. Despite…
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PRESENTATION 02/2014NOETUDE/C2014-027Biomonitoring of biphenol a and bisphenol s in urine using liquid chromatography-mass spectrometryAs an essential component of polycarbonate plastics and epoxy resins, Bisphenol A (BPA) is found in numerous industrial and consumer products, including electronic goods, household equipment, metallic food and beverage cans, bottles and dental…
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