Results of the search of scientific studies, publications and communications

Currently booming, hyperthermic intraperitoneal chemotherapy (HIPEC), also known as intraperitoneal hyperthermic chemoperfusion (IPHC), is a cancer treatment given in the operating theatre. It consists, after resection of the peritoneal metastatic…

Pregnant Sprague-Dawley rats were administered deltamethrin, at doses of 0.1, 1, 5, or 10 mg/kg/day, or di-n-hexyl phthalate (DnHP) (250 mg/kg/day), by gavage, from gestation day (GD) 13 to 19. Maternal toxicity was observed at 10 mg/kg/day, as evidenced by transient…

In a first study, rats were given diisooctyl phthalate (DIOP, CAS 27554-26-3) at 0, 0.1, 0.5, and 1 g/kg/day, by gavage, on gestation days 6 through 20 (GD). There was a significant increase in resorptions at 1 g/kg/day and a reduction in fetal weights at 0.5 and 1 g/kg…

DEHP is a phthalate plasticizer of PVC, classified as a Category 1B reproductive toxicant (EU). Soft PVC are very often plasticized with 40% (w/w) phthalates. As DEHP is weakly bound, the risk of contamination and cutaneous penetration should be considered…

In utero exposure to the phthalate ester plasticizer, di-n-hexyl phthalate (DnHP) is known to affect the development of the male reproductive system and induce alterations in androgen-dependent tissues of the male rat offspring. Male reproductive…

Outline of reasons and objectives
Di(isononyl) phthalate (DINP) is mainly used as a plasticizer in the flexible PVC industry, as a substitute for di(2-ethylhexyl) phthalate (DEHP). The industrial process is based on extrusion, and then gelling, in order…

Testing and assessment of chemicals for their endocrine disruption properties are a major concern for chemical safety. Besides regulatory studies which use standard markers (e.g. anogenital distance), more targeted mode of action studies can…

As an essential component of polycarbonate plastics and epoxy resins, Bisphenol A (BPA) is found in numerous industrial and consumer products, including electronic goods, household equipment, metallic food and beverage cans, bottles and dental…