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PRESENTATION 04/2015NOETUDE/C2015-051Optimization of mineralization methods of TiO2 nanoparticles: Determination of titanium levels in rat organ tissuesTitanium dioxide nanoparticles (TiO2 NPs) are among the highest produced nanoparticles in the world today and are increasingly being incorporated into a wide range of construction and domestic products. Production on such a massive scale raises…
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PRESENTATION 07/2014EL2013-010/C2014-066DEVELOPMENT AND VALIDATION OF AN INHALATION SYSTEM SUITABLE FOR RODENT EXPOSURE TO NANOAEROSOLSDue to the growing use of nanoparticles in industrial processes, the number of workers potentially exposed is increasing while the toxicological effects of these compounds have not been fully characterized yet. Because inhalation represents…
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PRESENTATION 10/2015NOETUDE/C2015-079Brain inflammation and Blood Brain Barrier disruption after sub-acute inhalation exposure to titanium dioxide nanoparticle aerosol in aging ratsNotwithstanding potential neurotoxicity of Titanium dioxide nanoparticles (TiO2 NPs), the toxicokinetics and consequences on blood brain barrier (BBB) functions remain poorly characterized. We previously described the biodistribution…
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STUDY 01/2013EL2013-010Study of the effect of agglomeration on the respiratory toxicological properties and the toxicokinetics of inhaled nanoparticles of titanium dioxide in ratsDue to the growing use of nanoparticles in industrial processes, the number of workers potentially exposed is increasing while the toxicological properties of these compounds are not fully known. Since these particles can be aerosolised, the…
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PUBLICATION 06/2025EL2022-001/P2025-043Simultaneous study of cochleotoxicity and vestibulotoxicity of 3,3 -iminodipropionitrile in rats through several experimental approaches.Many industrial chemicals and clinical compounds are toxic to the inner ear. Some preferentially target the cochlea or vestibular structures, whereas others are harmful to both. The reasons behind these distinct ototoxic profiles remain poorly…
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PRESENTATION 12/2014NOETUDE/C2014-120Biokinetic comparison after single I.V. administration or chronic aerosol inhalation of TiO2 nanoparticles : impact on blood-brain barrierNotwithstanding the translocation of reported TiO2 nanoparticles (NPs) through biological barriers, the bio-distribution of TiO2NPs to the CNS and impact on the functions of the BBB remain poorly characterized. We report such evidence.
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STUDY 01/2015EL2015-002Effects on hearing and on balance of co-exposure to low-frequency-rich noise and to a solvent: the carbon disulphide (CS2) modelAt workplaces, noise that is low-frequency rich is omnipresent and it can be associated with solvents, such as carbon disulphide, for example. That solvent, which is used in manufacturing cellulose and more particularly viscose, is known to give…
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STUDY 01/2017EL2017-001
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PUBLICATION 08/2023EL2017-001/P2023-111Three-dimensional cultured ampullae from rats as a screening tool for vestibulotoxicity: proof of concept using styreneNumerous ototoxic drugs, such as some antibiotics and chemotherapeutics, are both cochleotoxic and vestibulotoxic (causing hearing loss and vestibular disorders). However, the impact of some industrial cochleotoxic compounds on the vestibular…
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PUBLICATION 07/2018EL2015-002/P2018-095/ns362Effect on hearing and balance of a co-exposure to a low-frequency noise associated with carbon disulfide (CS2)Carbon disulfide (CS2) is a solvent used in the manufacture of cellulose, viscose fibers and sponges. Co-exposures to CS2 and noise are common. Occupational exposures to CS2 have been shown to cause low-frequency hearing loss and balance disorders…
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