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Updating Skin Permeability Data: A Systematic Review of Recent Research

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Cutaneous absorption parameters of xenobiotics are crucial in drug and cosmetic development, as well as in assessing environmental and occupational chemical risks. Despite the great variability in experimental condition designs due to loose international guidelines, datasets like HuskinDB have been created to report skin absorption endpoints. This review updates the available skin permeability data by rigorously compiling researches published between 2012 and 2021. Inclusion and exclusion criteria has been selected to establish the most harmonized and reusable database possible. Each criterion is discussed, and the need for good reporting practices for skin permeability measurements is highlighted. The Generative Topographic Mapping method is applied on the present dataset and compared to HuskinDB to monitor the progress in skin permeability research and locate chemotype of particular concern. The open-source dataset includes steady-state flux, maximum flux, and permeability coefficients results for tested substances, as well as relevant information on experimental parameters that can impact the data. It can be used to extract subsets of data for comparisons and to build predictive models.