Objective: To analyse the effect of co-exposures to physical and psychosocial factors (PSF) regarding the incidence of workplace injuries (WI) among care workers; to identify the work factors associated with the co-exposure combinations leading to the highest rates of WI.<br/> Methods: The study sample consisted of 4 418 care workers participating to the French Working Conditions Survey both in 2013 and 2016. WI were assessed during the 3-year follow-up by matching the databases of the National Health Insurance Funds compensation system. We assessed exposure for physical factors and PSF using factorial analyses and hierarchical clustering. We implemented a Poisson regression model with the WI incidence as the outcome and the clusters as independent variables of interest. Logistic regression model allowed identifying the work factors that predicted co-exposure combinations with a WI rate of 40%.<br/> Results: WI were highly related to both physical and psychosocial exposures. With low exposure to one or the other, there was no increased risk of WI. Physical factors and PSF potentiated each other and their co-exposure significantly increased the risk of WI, with model predicted rates per 1 000 persons-year for those most exposed to physical risk of 14.6 [4.5-24.8] with low PSF and 38.0 [29.8-46.3] with high PSF. Work factors that predicted co-exposure combinations with a rate of 40 WI were: working as nursing assistant or hospital services officer, poor scheduling, overtime, work-family imbalance and insufficient preventive measures.<br/> Conclusions: These findings can lead to reflection on the prevention of WI among care workers.
