Can a 12-gene expression signature predict the cell transforming potential of tumor promoting agents in Bhas 42 cells?
Publication
In the present study, we assess whether this signature would be the same for four other soluble transforming agents, i.e. mezerein, methylarsonic acid, cholic acid and quercetin. The treatment of Bhas 42 cells for 48h with mezerein modified the expression of the 12 genes of the signature according to the same profile as that of the TPA. However, methylarsonic acid and cholic acid gave an incomplete signature with changes in the expression of only 7 and 5 genes, respectively. Finally, quercetin treatment induced no change in the expression of all genes but exhibited higher cytotoxicty. These results suggest that among the transforming agents tested, some may share similar mechanisms of action leading to cell transformation while others may activate different additional pathways involved in such cellular process.
-
Technical datasheet
-
Year of publication
2023 -
Language
Anglais -
Discipline(s)
Toxicologie expérimentale -
Author(s)
-
Reference
Toxicology Letters Volume 389, 1 November 2023, Pages 11-18
-