Results of the search of scientific studies, publications and communications

Phthalates are suspected to be endocrine disruptors. Di(2-ethylhexyl) phthalate (DEHP) is assumed to have low dermal absorption; however, previous in vitro skin permeation studies have shown large permeation differences. Our aims were to determine…

Outline of reasons and objectives
Di(isononyl) phthalate (DINP) is mainly used as a plasticizer in the flexible PVC industry, as a substitute for di(2-ethylhexyl) phthalate (DEHP). The industrial process is based on extrusion, and then gelling, in order…

DEHP is a phthalate plasticizer of PVC, classified as a Category 1B reproductive toxicant (EU). Soft PVC are very often plasticized with 40% (w/w) phthalates. As DEHP is weakly bound, the risk of contamination and cutaneous penetration should be considered…

Phthalates are economically important products with the most used for the tonnage implemented annually in the European Union can exceed 500,000 tons. They are used as plasticizers for plastics to make them more flexible, mainly in the polyvinyl…

In this study the workers’exposure to di(2-ethylhexyl)phthalate (DEHP), in six French factories, was assessed. Over 5 days of pre-and post-shift sampling, three urinary metabolites of DEHP, mono (2-ethylhexyl) phthalate (MEHP), mono (5-carboxy-2-ethylpentyl…

At INRS, in 2012, a study on the need for epidemiological research in the working environment on endocrine disruptors (reproductive effect) pointed to phthalates (DiNP, DEHP) as a priority class of substances to be examined. It is expected that DiNP…