List of scientific publications

Background: Noise is one of the most pervasive hazardous factors in the workplace. Despite regulations, noise-induced hearing loss is a common disease. To prevent such a scourge, pure-tone air-conduction audiometry (PTA) is the reference test…

Human and animal studies have shown that noise and ototoxic agents such as aromatic solvents can cause hearing loss or can exacerbate noise-induced hearing loss. The synergistic effects are partly due to a modification of the efferent reflex…

1. Toluene (TOL) is a CMR solvent which is metabolized via the glutathione pathway, producing benzylmercapturic, o-, m- and p-toluylmercapturic acids (MAs). These metabolites could be useful as biomarkers of TOL exposure.
2. The aims of this work were…

Phthalates are diesters of the ortho phthalic acid. They are extensively used as plasticizers, primarily for polyvinyl chloride (PVC), and as solvents. They are present in a large variety of consumer products and widespread exposure to multiple…

Synthetic pyrethroids are present in numerous commercial insecticide formulations and have extensive worldwide indoor and outdoor applications, including agricultural, public, residential, and veterinary usages for pest control. Their…

The solvent N-ethyl-2-pyrrolidone was evaluated in a 4-week repeated dose study in rats. NEP diluted in distilled water was administered by gavage to male and female Sprague-Dawley rats at doses of 0 (vehicle control), 5, 50, and 250 mg/kg/day for 28…

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Since more than twenty years, research has shown that certain substances, called ototoxics, can provoke a chemical-induced hearing loss, or exacerbate the noise-induced hearing loss. And it is quite common that an individual is exposed to several…

The olivocochlear and stapedial reflexes are both involved in hearing physiology: the first one is mainly dedicated to the high frequency discrimination, whereas the second protects the cochlea by contracting the middle-ear muscles. In the…

The mechanisms of action involved in the neurotoxicity of solvents are poorly understood. Studies have suggested that the effects of some solvents might be due to the formation of reactive oxygen species (ROS). This study assesses hydroxyl radical…