List of scientific presentations

Discipline(s) : Toxicologie expérimentale

29 results

Epigenetic mechanisms involvement in in vitro cell transformation induced by micro- and nano-silica particles NOETUDE/C2016-087 | 2016

Epigenetic mechanisms that are essential in normal cell growth have been found disrupted in several human diseases such as cancer. Epigenetic mechanisms include histone post-translational modifications, DNA methylation and non-coding…
DEVELOPMENT AND VALIDATION OF AN INHALATION SYSTEM SUITABLE FOR RODENT EXPOSURE TO NANOAEROSOLS EL2013-010/C2014-066 | 2014

Due to the growing use of nanoparticles in industrial processes, the number of workers potentially exposed is increasing while the toxicological effects of these compounds have not been fully characterized yet. Because inhalation represents…
Evaluation of N-ethyl-2-pyrrolidone-induced liver effects in rats NOETUDE/C2016-072 | 2016

N-ethyl-2-pyrrolidone (NEP) is an industrial solvent used in association or in replacement of N-methyl-2-pyrrolidone. Both are teratogenic in rats and are categorized as reproductive toxicants 1B by the European Commission. Nevertheless…
Optimization of mineralization methods of TiO2 nanoparticles: Determination of titanium levels in rat organ tissues NOETUDE/C2015-051 | 2015

Titanium dioxide nanoparticles (TiO2 NPs) are among the highest produced nanoparticles in the world today and are increasingly being incorporated into a wide range of construction and domestic products. Production on such a massive scale raises…
Artificial sebum as a vehicle for studying ex vivo percutaneous absorption of three solid and lipophilic industrial toxicants B.4/2.165/C2016-008 | 2016

For testing skin absorption of chemical substances, OECD Test Guideline 428 (OECD, 2004)1 provides some recommendations as to how substances should be prepared:
“The test substance preparation (e.g., neat, diluted or formulated material containing…
EchoScan: a new preventive tool for hearing loss prevention NOETUDE/C2013-119 | 2013

Human and animal studies have shown that noise and ototoxic agents such as aromatic solvents can cause hearing loss or can exacerbate noise-induced hearing loss. The synergistic effects are partly due to a modification of the efferent reflex…
Auditory fatigue: a new challenge in prevention NOETUDE/C2016-041 | 2016

Aromatic solvents can provoke deafness. The diagnostic of occupational deafness is carried out by pure-tone audiometry, a technique which is capable of testing the perception of auditory messages at the central level. But this technique could…
Neuropharmacological and cochleotoxic effects of styrene can worsen the noise impact EL2013-023/C2016-094 | 2016

It is well-known that occupational noise exposure can damage workers' hearing. It is also well accepted that a combined exposure to noise with cochleotoxic substances (antibiotics, cisplatin…) or ototoxic agents such as aromatic solvents (toluene…
Titaninium dioxide-induced gene expression profile in rat lung, a sub-acute inhalation study. EL2013-010/C2016-018 | 2016

Due to the growing use of nanoparticles in industrial processes, the number of workers potentially exposed is increasing while the toxicological properties of these compounds are not fully known. Inhalation represents the main route of occupational…
Aromatic solvents disturb the stapedial reflex involved in hearing NOETUDE/C2015-053 | 2015

The olivocochlear and stapedial reflexes are both involved in hearing physiology: the first one is mainly dedicated to the high frequency discrimination, whereas the second protects the cochlea by contracting the middle-ear muscles. In the…

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