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https://en.inrs.fr/home/our-activities/studies-and-research/studies-publications-communications/doc/presentation.html?refINRS=NOETUDE%2FC2016-072
N-ethyl-2-pyrrolidone (NEP) is an industrial solvent used in association or in replacement of N-methyl-2-pyrrolidone. Both are teratogenic in rats and are categorized as reproductive toxicants 1B by the European Commission. Nevertheless…
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https://en.inrs.fr/home/our-activities/studies-and-research/studies-publications-communications/doc/presentation.html?refINRS=NOETUDE%2FC2015-051
Titanium dioxide nanoparticles (TiO2 NPs) are among the highest produced nanoparticles in the world today and are increasingly being incorporated into a wide range of construction and domestic products. Production on such a massive scale raises…
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https://en.inrs.fr/home/our-activities/studies-and-research/studies-publications-communications/doc/presentation.html?refINRS=EL2013-023%2FC2016-094
It is well-known that occupational noise exposure can damage workers' hearing. It is also well accepted that a combined exposure to noise with cochleotoxic substances (antibiotics, cisplatin…) or ototoxic agents such as aromatic solvents (toluene…
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https://en.inrs.fr/home/our-activities/studies-and-research/studies-publications-communications/doc/presentation.html?refINRS=NOETUDE%2FC2015-079
Notwithstanding potential neurotoxicity of Titanium dioxide nanoparticles (TiO2 NPs), the toxicokinetics and consequences on blood brain barrier (BBB) functions remain poorly characterized. We previously described the biodistribution…
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https://en.inrs.fr/home/our-activities/studies-and-research/studies-publications-communications/doc/presentation.html?refINRS=NOETUDE%2FC2016-146
Testing and assessment of chemicals for their endocrine disruption properties are a major concern for chemical safety. Besides regulatory studies which use standard markers (e.g. anogenital distance), more targeted mode of action studies can…
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https://en.inrs.fr/home/our-activities/studies-and-research/studies-publications-communications/doc/presentation.html?refINRS=NOETUDE%2FC2015-041
Pyrethroids are among the most commonly used classes of insecticides worldwide. Human exposure to pyrethroids is widespread, as evidenced by the presence of their metabolites in urine of adults, children, and pregnant and lactating women among…
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https://en.inrs.fr/home/our-activities/studies-and-research/studies-publications-communications/doc/presentation.html?refINRS=EL2013-010%2FC2016-102
Due to the growing use of nanoparticles in industrial processes, the number of workers potentially exposed is increasing while the toxicological properties of these compounds are not fully known. Inhalation represents the main route of occupational…
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https://en.inrs.fr/home/our-activities/studies-and-research/studies-publications-communications/doc/presentation.html?refINRS=NOETUDE%2FC2015-056
The olivocochlear and stapedial reflexes are both involved in hearing physiology: the first one is mainly dedicated to the high frequency discrimination, whereas the second protects the cochlea by contracting the middle-ear muscles. In the…
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https://en.inrs.fr/home/our-activities/studies-and-research/studies-publications-communications/doc/presentation.html?refINRS=NOETUDE%2FC2014-015
Phthalates are diesters of the ortho phthalic acid. They are extensively used as plasticizers, primarily for polyvinyl chloride (PVC), and as solvents. They are present in a large variety of consumer products and widespread exposure to multiple…
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https://en.inrs.fr/home/our-activities/studies-and-research/studies-publications-communications/doc/presentation.html?refINRS=NOETUDE%2FC2014-120
Notwithstanding the translocation of reported TiO2 nanoparticles (NPs) through biological barriers, the bio-distribution of TiO2NPs to the CNS and impact on the functions of the BBB remain poorly characterized. We report such evidence.
Adult…